Continuous Bioenergetics with Resipher
Continuous Bioenergetics
Resipher
Bioenergetic profiling of mitochondrial ETC function, FAO substrate metabolism, and beyond.
Long-term baselines for stable, basal respiration
Parallel independent treatments to measure functional parameters including ATP-linked respiration, spare capacity, and proton leak
Standard plate compatibility for use with 2D and 3D models in any media type
Resipher is a truly non-invasive metabolic cell analyzer that works with your cell culture and your well plates.
Standard 96-well plates including flat bottom, round bottom, v-bottom, collagen-coated, glass-bottom, and custom.
Any culture type from 2D monolayer to 3D organoids, tissue slices, embryos, and even whole organisms.
Resipher integrates easily into your existing standard incubator workflow for experiments lasting days to weeks to months.
The Resipher has been pivotal to our work studying oxygen availability in cell culture as it offered the unique ability to measure oxygen concentrations of the cellular microenvironment straight in the incubator and without having to manipulate the cells. Getting OCR readouts alongside was a huge bonus and gave us new insight into the cells’ metabolism.
Before Resipher, we struggled to longitudinally track the changes in the metabolic states of our cells in their standard incubator and under standard culture conditions. The Resipher system offered us a fantastic opportunity. Since then, Resipher has become integral to every single project in our lab. The machine runs day and night, weekends and holidays. In other words, Resipher has become the mainstay of our research. The best part is that we can monitor the OCR of our cells from anywhere, even from bed. Highly recommended!
The Resipher allows my lab to continuously measure oxygen consumption rates of our retinal cells in real-time while they’re in the incubator over several weeks on end. It has enabled us to uncover novel insights into retinal cell metabolism and mitochondrial dysfunction as well as screen metabolic targeting drugs for the treatment of age-related macular degeneration.
I have been using Resipher to determine lung airway epithelial cells' oxygen consumption rate (OCR). Lucid Scientific's technical support team is excellent.
Resipher is an outstanding addition to the field of mitochondrial biology. It perfectly complements end-point assays by introducing live-cell recordings of oxygen consumption, something that was not previously available. I immediately saw the value in the technology; it was one of my first investments when I opened my lab, and my two units now run 24/7. The system is also remarkably easy to use, so new lab members get up to speed quickly. Over the years, the investment has paid off many times over, from enabling new experimental approaches to opening the door to my favorite thing in science: collaboration. I collaborate with many colleagues using Resipher's live-cell capabilities, as well as with Lucid Scientific itself. Their team is simply amazing.